Lab for Translational Molecular Neuroimaging (TMN)
We bring together Nuclear Medicine, Neuroscience, Data Science, and Clinical Medicine to advance the understanding, diagnosis, and treatment of neurodegenerative diseases. We develop and employ innovative molecular imaging tools and biomarkers to study brain disease in vivo. By combining advanced imaging with computational analysis and disease modeling, we bridge discoveries from organoids and preclinical studies to clinical application. Through a strong international network of collaborators, we promote scientific innovation, translational research, and training in nuclear medicine and neuroimaging.
Research Focus:
Molecular imaging tracers for neurodegenerative disorders, with particular emphasis on:
- Proteinopathies (e.g., amyloid, tau, α-synuclein)
- Neuroinflammation and glial activation
- Synaptic integrity and dysfunction
- Neuroreceptor systems
Development of Innovative Methodologies:
- Design and validation of novel molecular imaging tracers
- Development of Non-Animal Methods (NAMs) for translational research
- Advanced image analysis, biomarker discovery, and disease modeling
Multimodal & Multiscale Imaging:
We integrate PET, SPECT, MRI, and complementary imaging modalities with molecular, cellular, and computational data to achieve a multiscale understanding of brain pathology — from molecular mechanisms to clinical phenotypes.
Ongoing projects
- Endoimaging (BMCC)
- AutoFUS (SNSF JPND)
- Alpha-Synuclein imaging (Novartis foundation for Medical Biological Research)